A variety of her fellow college students thought she might some day turn out to be the first feminine president of the United States. Clinton made a second presidential run in 2016, profitable the Democratic nomination, and ran in the basic election with Virginia senator Tim Kaine as her operating mate. Clinton lost the presidential election to Republican opponent Donald Trump within the Electoral College, regardless of winning the popular vote. Following her loss, she wrote her third memoir, What Happened, and launched Onward Together, a political action organization devoted to fundraising for progressive political teams. In 2000, Clinton was elected as the primary female senator from New York and have become the first First woman to concurrently hold elected workplace, after which the first former First girl to serve within the Senate.
The biggest threat to her campaign was her previous support of the Iraq War, which Obama had opposed from the beginning. Clinton and Obama each set records for early fundraising, swapping the money lead each quarter.At the end of October, Clinton fared poorly in her debate performance against Obama, Edwards, and her other opponents. Obama's message of change began to resonate with the Democratic voters higher than Clinton's message of experience. When New York's long-serving U.S. senator Daniel Patrick Moynihan introduced his retirement in November 1998, a number of outstanding Democratic figures, together with Representative Charles Rangel of New York, urged Clinton to run for his open seat in the Senate election of 2000.